Michael R Hayden Selected Research

polyglutamine

1/2022	Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice.
10/2021	Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.
11/2020	Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies.
10/2020	Compromised IGF signaling causes caspase-6 activation in Huntington disease.
1/2019	Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.
1/2019	Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.
1/2018	Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
6/2015	HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
5/2015	Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.
4/2015	Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

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Michael R Hayden Research Topics

Disease

126	Huntington Disease (Huntington's Disease) 08/2022 - 02/2002
42	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2022 - 05/2004
16	Atherosclerosis 11/2017 - 01/2002
11	Neoplasms (Cancer) 01/2019 - 01/2011
11	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 05/2004
9	Inflammation (Inflammations) 01/2018 - 03/2009
9	Drug-Related Side Effects and Adverse Reactions 01/2018 - 03/2007
9	Tangier Disease 01/2015 - 10/2002
9	Hypertriglyceridemia 01/2011 - 11/2002
8	Mitochondrial Diseases (Mitochondrial Disease) 08/2022 - 02/2006
8	Atrophy 06/2019 - 04/2002
8	Disease Progression 01/2019 - 11/2002
8	Type 2 Diabetes Mellitus (MODY) 01/2016 - 03/2007
7	Multiple Sclerosis 11/2017 - 05/2015
7	Cardiotoxicity 01/2017 - 09/2011
6	Insulin Resistance 01/2018 - 01/2008
5	Cognitive Dysfunction 10/2018 - 04/2005
5	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 08/2006 - 10/2002
4	Glucose Intolerance 01/2016 - 01/2010
4	Cardiovascular Diseases (Cardiovascular Disease) 04/2015 - 01/2002
4	Coronary Artery Disease (Coronary Atherosclerosis) 03/2012 - 10/2004
4	Pancreatitis 02/2009 - 09/2004
3	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2016
3	Ototoxicity 01/2018 - 12/2009
3	Body Weight (Weight, Body) 04/2015 - 04/2010
3	Obesity 03/2014 - 03/2009
3	Hyperlipidemias (Hyperlipidemia) 08/2009 - 11/2002
3	Juvenile Amyotrophic Lateral Sclerosis 2 01/2007 - 12/2003
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 12/2016
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2019 - 01/2015
2	Parkinsonian Disorders (Parkinsonism) 01/2019 - 01/2019
2	Hearing Loss (Hearing Impairment) 01/2018 - 12/2009
2	Testicular Neoplasms (Testicular Cancer) 01/2018 - 11/2017
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2018 - 12/2009
2	Neuroinflammatory Diseases 04/2015 - 06/2013
2	Gliosis 03/2015 - 06/2013
2	Hemorrhage 06/2014 - 01/2013
2	Carcinogenesis 02/2014 - 10/2002
2	Pain (Aches) 01/2013 - 08/2011

Drug/Important Bio-Agent (IBA)

44	polyglutamineIBA 01/2022 - 02/2002
32	Proteins (Proteins, Gene)FDA Link 08/2022 - 02/2002
21	CholesterolIBA 04/2021 - 01/2002
17	Huntingtin ProteinIBA 08/2022 - 08/2002
14	Caspase 6IBA 10/2020 - 01/2011
14	Pharmaceutical PreparationsIBA 01/2019 - 03/2007
13	HDL CholesterolIBA 04/2015 - 11/2004
11	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019 - 03/2002
9	LipidsIBA 01/2018 - 08/2003
9	Triglycerides (Triacylglycerol)IBA 03/2014 - 11/2002
8	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 08/2009 - 09/2004
7	pridopidineIBA 11/2021 - 01/2016
7	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 07/2002
7	CaspasesIBA 01/2018 - 09/2002
7	AnthracyclinesIBA 01/2017 - 09/2011
6	ATP-Binding Cassette Transporters (ABC Transporters)IBA 03/2012 - 06/2003
5	Sigma-1 ReceptorIBA 11/2021 - 01/2019
5	laquinimodIBA 06/2019 - 01/2016
5	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 12/2009
5	Amyloid (Amyloid Fibrils)IBA 01/2017 - 12/2005
5	Insulin (Novolin)FDA Link 08/2016 - 01/2008
5	Glucose (Dextrose)FDA LinkGeneric 04/2015 - 01/2008
5	Mutant Proteins (Protein, Mutant)IBA 01/2014 - 08/2002
5	Opioid Analgesics (Opioids)IBA 05/2013 - 10/2010
4	LDL Receptors (LDL Receptor)IBA 10/2019 - 04/2006
4	HDL LipoproteinsIBA 11/2017 - 10/2005
4	Glatiramer Acetate (Copaxone)FDA Link 11/2017 - 05/2015
4	CalciumIBA 01/2016 - 08/2002
4	Antisense OligonucleotidesIBA 01/2014 - 12/2011
4	Codeine (Codeine Phosphate)FDA LinkGeneric 01/2013 - 08/2011
4	Lipoproteins (Lipoprotein)IBA 01/2011 - 02/2008
4	Adenosine Triphosphate (ATP)IBA 02/2010 - 10/2002
4	Apolipoproteins E (ApoE)IBA 08/2009 - 12/2005
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2005
3	Neuroprotective AgentsIBA 11/2021 - 12/2012
3	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 10/2005
3	Steroid 12-alpha-Hydroxylase (CYP8B1)IBA 01/2018 - 04/2015
3	Peptides (Polypeptides)IBA 11/2017 - 01/2012
3	Insulin-Like Growth Factor I (IGF-1)IBA 08/2016 - 04/2010
3	Monoamine Oxidase (MAO)IBA 04/2016 - 12/2015
3	Warfarin (Coumadin)FDA LinkGeneric 06/2014 - 09/2011
3	TransferasesIBA 11/2013 - 12/2009
3	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 12/2012 - 08/2011
3	stearoyl-coenzyme A (stearoyl-CoA)IBA 12/2009 - 01/2008
3	N-Methylaspartate (NMDA)IBA 09/2009 - 02/2007
3	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2009 - 10/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2022 - 01/2016
2	MicroRNAs (MicroRNA)IBA 10/2020 - 03/2016
2	Vincristine (Oncovin)FDA LinkGeneric 01/2019 - 04/2013
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 11/2010
2	Bile Acids and Salts (Bile Acids)IBA 01/2018 - 01/2018
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2018 - 02/2014
2	Histone Deacetylase InhibitorsIBA 01/2017 - 10/2006
2	CytokinesIBA 01/2016 - 05/2004
2	Genetic Markers (Genetic Marker)IBA 01/2016 - 09/2010
2	ATP Binding Cassette Transporter 1IBA 01/2016 - 05/2005
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2016 - 01/2016
2	Methotrexate (Mexate)FDA LinkGeneric 04/2013 - 01/2013

Therapy/Procedure

18	Therapeutics 08/2022 - 04/2005
3	Drug Therapy (Chemotherapy) 11/2017 - 12/2009
2	Cesarean Section (Caesarean Section) 01/2013 - 08/2011